Pi3k inhibitor and reduced metabolism
At the opposite end of the beneficial effects of reduced PI3K and DR are the detrimental effects of hypercaloric and fat-rich diets. This finding reinforces the concept that PI3Kα inhibition is a relevant mediator of the link between PI3K and metabolism, which is in agreement with previous observations in mice with partial decrease of Cited by: A phosphoinositide 3-kinase inhibitor (PI3K inhibitor) is a class of medical drug that functions by inhibiting one or more of the phosphoinositide 3-kinase enzymes, which are part of the PI3K/AKT/mTOR pathway, an important signalling pathway for many cellular functions such as growth control, metabolism and translation initiation. As shown previously the PI3K inhibitor LY reduced HKII levels and lactate production in various multiple myeloma cells. It is known that PI3K/Akt stimulates the coupling of HKII to a voltage-dependent anion channel (VDAC) on the mitochondrial membrane thereby improving cell area907.info by: 9.